Vascularized Composite Allograft Transplant Survival in Miniature Swine
نویسندگان
چکیده
منابع مشابه
Ex Situ Limb Perfusion System to Extend Vascularized Composite Tissue Allograft Survival in Swine.
BACKGROUND Organ perfusion systems have successfully been applied in solid organ transplantations. Their use in limb transplantation and replantation has not been widely investigated. In this study, we tested the potential for ex situ perfusion system to prolong limb allograft viability in a swine forelimb amputation/replantation model. METHODS Fourteen swine were used. In group 1 (n = 4), we...
متن کاملThe Effect of Ex Situ Perfusion in a Swine Limb Vascularized Composite Tissue Allograft on Survival up to 24 Hours.
PURPOSE To test the potential for the ex situ limb perfusion system to prolong limb allograft survival up to 24 hours. METHODS We used 20 swine for the study. In group 1 (control), 4 limbs were perfused with heparin solution and preserved at 4°C for 6 hours. In group 2, 4 limbs were perfused with autologous blood at 27°C to 32°C for 24 hours. In both groups, limbs were transplanted orthotopic...
متن کاملA modified heterotopic swine hind limb transplant model for translational vascularized composite allotransplantation (VCA) research.
Vascularized Composite Allotransplantation (VCA) such as hand and face transplants represent a viable treatment option for complex musculoskeletal trauma and devastating tissue loss. Despite favorable and highly encouraging early and intermediate functional outcomes, rejection of the highly immunogenic skin component of a VCA and potential adverse effects of chronic multi-drug immunosuppression...
متن کاملEffect of class II antigen matching on renal allograft survival in miniature swine
The benefit of class II major histocompatibility complex (MHC) antigen matching to renal allograft survival, in the absence of immunosuppression, has been studied in partially inbred miniature swine. Permanent (greater than 6 mo) renal allograft survival was found in 30% of recipients of either class II only or fully matched grafts. Analysis of the survival of the class II-only matched grafts b...
متن کاملAbstract P26. The Ratio And Time Effect: Administration Of Il-2-anti-il-2 Complexes Controls Vascularized Composite Allograft Survival.
METHODS: We performed the VCA model utilizing Balb/c mice as donor and C57bl/10 mice as recipient. Mice were divided randomly to 6 groups (n=15/group). Group A: control; Group B: post-Tx. IL-2C (inj. POD 0, 1, 2); Group C: Rapamycin (2mg/kg, 28days); Group D: Rapamycin plus post-Tx. IL-2C; Group E: pre-Tx. IL-2C (POD -5, -4, -3); Group F: Rapamycin plus pre-Tx. IL-2C. Signs of allograft rejecti...
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ژورنال
عنوان ژورنال: Transplantation
سال: 2013
ISSN: 0041-1337
DOI: 10.1097/tp.0b013e3182a579d0